MDC1 (phospho S513), Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MDC1.

Brand:  Abnova PAB29247.100uL

Product Code. 16254240

Description

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq

Specifications

• Antigen: MDC1
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MDC1.
• Formulation: In PBS, pH 7.4 (without Mg²⁺ and Ca²⁺), (50% glycerol, 0.02% sodium azide)
• Gene Alias: DKFZp781A0122/KIAA0170/MGC166888/NFBD1
• Host Species: Rabbit
• Purification Method: Affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 9656
• Target Species: Human
• Form: Liquid

• Applications: Immunohistochemistry (PFA fixed)
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (1:50-1:100) The optimal working dilution should be determined by the end user.
• Gene: MDC1
• Gene Symbols: MDC1
• Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S513 of human MDC1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: This antibody detects endogenous levels of MDC1 only when phosphorylated at serine 513.
• Content And Storage: Store at -20°C.
  Avoid repeated freezing and thawing.

For Research Use Only