MAP3K7IP1 Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of MAP3K7IP1.

Brand:  Abnova PAB12935.100ug

Product Code. 16080267

Description

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq

Specifications

• Antigen: MAP3K7IP1
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of MAP3K7IP1.
• Formulation: In PBS (0.02% sodium azide)
• Gene Alias: 3'-Tab1/MGC57664/TAB1
• Host Species: Rabbit
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Form: Liquid

• Applications: Immunocytochemistry, Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: MAP3K7IP1
• Gene Symbols: MAP3K7IP1
• Immunogen: A synthetic peptide corresponding to internal region 13 amino acids of human MAP3K7IP1.
• Regulatory Status: RUO
• Gene ID (Entrez): 10454
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only