IKBKB (phospho T199), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of IKBKB.

Brand:  Abnova PAB18519.100ug

Product Code. 16073127

Description

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM

Specifications

• Antigen: IKBKB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Dilution: Immunofluorescence (1:100-1:200) The optimal working dilution should be determined by the end user.
• Gene: IKBKB
• Gene Symbols: IKBKB
• Immunogen: Synthetic phosphopeptide corresponding to residues surrounding T199 of human IKBKB.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: This antibody is specific to IKBKB only when phosphorylated at T199.
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: Immunofluorescence
• Concentration: 1 mg/mL
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of IKBKB.
• Formulation: In PBS, 150mM NaCl, pH 7.4 (0.02% sodium azide, 50% glycerol).
• Gene Alias: FLJ40509/IKK-beta/IKK2/IKKB/MGC131801/NFKBIKB
• Host Species: Rabbit
• Purification Method: Affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 3551
• Target Species: Human, Mouse, Rat
• Form: Liquid

For Research Use Only