GRM7, Rabbit, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of GRM7.

Brand:  Abnova PAB26521.50ug

Product Code. 16076697

Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Specifications

• Antigen: GRM7
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of GRM7.
• Formulation: In PBS (0.09% sodium azide)
• Gene Accession No.: Q14831
• Gene Symbols: GRM7
• Immunogen: A synthetic peptide corresponding to 19 amino acids at N-terminal extracellular domain of human GRM7.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Test Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM8 (63%).
• Content And Storage: Store at 4°C. For long term storage store at -80°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: Immunocytochemistry, Immunohistochemistry (PFA fixed), Western Blot
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (6-16 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: GRM7
• Gene Alias: FLJ40498/GLUR7/GPRC1G/MGLUR7/mGlu7
• Host Species: Rabbit
• Purification Method: Immunoaffinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2917
• Target Species: Bovine, Human
• Form: Liquid

For Research Use Only