GALR2, Rabbit, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of GALR2.

Brand:  Abnova PAB26012.50ug

Product Code. 16076197

Description

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq

Specifications

• Antigen: GALR2
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of GALR2.
• Formulation: In PBS (0.09% sodium azide)
• Gene Accession No.: O43603
• Gene Symbols: GALR2
• Immunogen: A synthetic peptide corresponding to 18 amino acids at transmembrane domain of human GALR2.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Test Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Content And Storage: Store at 4°C. For long term storage store at -80°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: Immunohistochemistry (PFA fixed)
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (40 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: GALR2
• Gene Alias: GALNR2/MGC125983/MGC125984
• Host Species: Rabbit
• Purification Method: Immunoaffinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8811
• Target Species: Human
• Form: Liquid

For Research Use Only