FBXW7, Rabbit, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of FBXW7.

Brand:  Abnova PAB9873.100ug

Product Code. 16061958

Description

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq]

Specifications

• Antigen: FBXW7
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of FBXW7.
• Formulation: In PBS (0.08% sodium azide)
• Gene Alias: AGO/CDC4/DKFZp686F23254/FBW6/FBW7/FBX30/FBXO30/FBXW6/FLJ16457/SEL-10/SEL10
• Host Species: Rabbit
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid

• Applications: Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (1-5 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: FBXW7
• Gene Symbols: FBXW7
• Immunogen: A synthetic peptide corresponding to human FBXW7.
• Regulatory Status: RUO
• Gene ID (Entrez): 55294
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only