CXCR2 Rabbit anti-Human, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of CXCR2.

Brand:  Abnova PAB7969.100ug

Product Code. 16224500

Description

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq

Specifications

• Antigen: CXCR2
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of CXCR2.
• Formulation: Lyophilized from 0.9mg NaCl, 0.2mg Na₂HPO₄ (5mg BSA, 0.05mg sodium azide, 0.05mg Thimerosal)
• Gene Alias: CD182/CDw128b/CMKAR2/IL8R2/IL8RA/IL8RB
• Host Species: Rabbit
• Purification Method: Affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 3579
• Content And Storage: Store at -20°C on dry atmosphere. After reconstitution with 200μL of deionized water and concentration will be 500μ/mL store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG

• Applications: Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (1 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: CXCR2
• Gene Symbols: CXCR2
• Immunogen: A synthetic peptide corresponding to amino acids at internal region of human CXCR2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Form: Lyophilized

For Research Use Only