AGTR2 Rabbit anti-Bovine, Dog, Hamster, Horse, Human, Monkey, Mouse, Pig, Rat, Sheep, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of AGTR2.

Brand:  Abnova PAB25552.50ug

Product Code. 16015727

Description

Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors termed AT1 and AT2. AGTR2 belongs to a family 1 of G-protein coupled receptors. It is an integral membrane protein. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death (apoptosis). In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. The human AGTR2 gene is composed of three exons and spans at least 5kb. Exons 1 and 2 encode for 5' untranslated mRNA sequence and exon 3 harbors the entire uninterrupted open reading frame. [provided by RefSeq]

Specifications

• Antigen: AGTR2
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of AGTR2.
• Formulation: In PBS (0.09% sodium azide)
• Gene Alias: AT2/ATGR2/MRX88
• Host Species: Rabbit
• Purification Method: Immunoaffinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 186
• Target Species: Bovine, Canine, Equine, Hamster, Human, Monkey, Mouse, Pig, Rat, Sheep
• Form: Liquid

• Applications: Immunohistochemistry (PFA fixed)
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: AGTR2
• Gene Symbols: AGTR2
• Immunogen: A synthetic peptide corresponding to 16 amino acids at internal region of human AGTR2.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Test Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR65 (63%), NPFFR2 (44%).
• Content And Storage: Store at 4°C. For long term storage store at -80°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only