Invitrogen™ RAB8A Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA579906

Product Code. 15905475

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: Caco-2 whole cell, HepG2 whole cell, A549 whole cell. IHC: Human Intestinal Cancer Tissue, Human Mammary Cancer Tissue.

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.

Specifications

• Antigen: RAB8A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RAB8A
• Gene Alias: AA409338; cell line NK14 derived transforming oncogene; MEL; mel transforming oncogene (derived from cell line NK14); mel transforming oncogene (derived from cell line NK14)- RAB8 homolog; mel transforming oncogene (RAB8 homolog); oncogene c-mel; Rab8; Rab8a; RAB8A, member RAS oncogene family; ras-associated protein RAB8; ras-related protein Rab-8A
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4218
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide, 0.05mg thimerosal
• Gene Accession No.: P61006
• Gene Symbols: RAB8A
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human RAB8A (170-183aa KAKMDKKLEGNSPQ).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG