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  8. R406 free base, MedChemExpress

R406 free base, MedChemExpress

Product Code. 16494398
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Product Code. 16494398 Supplier Medchem Express Supplier No. HY11108

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Description

MedChemExpress R406 free base is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 free base reduces immune complex-mediated inflammation. R406 free base also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).

R406 free base is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 free base reduces immune complex-mediated inflammation. R406 free base also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).

Specifications

Chemical Name or Material R406 free base
CAS 841290-80-0
Color Light Yellow
Purity Grade Notes Research
Molecular Formula C22H23FN6O5
Quantity 10 mg
Solubility Information DMSO : ≥ 10 mg/mL (21.26 mM)
SMILES COC1=CC(NC2=NC(NC3=NC(N4)=C(C=C3)OC(C)(C)C4=O)=C(C=N2)F)=CC(OC)=C1OC
Molecular Weight (g/mol) 470.45
Formula Weight 470.45
Percent Purity 98.15%
Grade Research
Physical Form Solid
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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