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R-268712, MedChemExpress

Product Code. 16496036
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Product Code. 16496036 Supplier Medchem Express Supplier No. HY12953

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Description

MedChemExpress R-268712 is an orally active and selective ALK-5 inhibitor, with an IC50 of 2.5 nM. R-268712 inhibits the phosphorylation of Smad3 in a dose-dependent manner with an IC50 of 10.4 nM. R-268712 suppresses glomerulonephritis as well as glomerulosclerosis by inhibiting TGF-β signaling, which can be used in studies of renal fibrosis and cancer.

R-268712 is an orally active and selective ALK-5 inhibitor, with an IC50 of 2.5 nM. R-268712 inhibits the phosphorylation of Smad3 in a dose-dependent manner with an IC50 of 10.4 nM. R-268712 suppresses glomerulonephritis as well as glomerulosclerosis by inhibiting TGF-β signaling, which can be used in studies of renal fibrosis and cancer.

Specifications

Chemical Name or Material R-268712
CAS 879487-87-3
Color Light Yellow
Purity Grade Notes Research
Molecular Formula C20H18FN5O
Quantity 100 mg
Solubility Information DMSO : 125 mg/mL (343.98 mM; Need ultrasonic)
SMILES FC1=C(C2=CN(CCO)N=C2)C=C(C3=CNN=C3C4=CC=CC(C)=N4)C=C1
Molecular Weight (g/mol) 363.39
Formula Weight 363.39
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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