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Pyridone 6, MedChemExpress

Product Code. 16466068
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Product Code. 16466068

Brand: Medchem Express HY14435

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Description

MedChemExpress Pyridone 6 is a pan-JAK inhibitor, which potently inhibits the JAK kinase family, with IC50s of 1 nM for JAK2 and TYK2, 5 nM for JAK3, and 15 nM for JAK1, while displaying significantly weaker affinities (130 nM to >10 mM) for other protein tyrosine kinases.

Pyridone 6 is a pan-JAK inhibitor, which potently inhibits the JAK kinase family, with IC50s of 1 nM for JAK2 and TYK2, 5 nM for JAK3, and 15 nM for JAK1, while displaying significantly weaker affinities (130 nM to >10 mM) for other protein tyrosine kinases.

Specifications

Chemical Name or Material Pyridone 6
CAS 457081-03-7
Color Brown
Purity Grade Notes Research
Molecular Formula C18H16FN3O
Quantity 10 mg
Solubility Information DMSO : ≥ 100 mg/mL (323.27 mM)
SMILES FC1=CC2=C(C(NC=C3)=O)C3=C(N=C(C(C)(C)C)N4)C4=C2C=C1
Molecular Weight (g/mol) 309.34
Formula Weight 309.34
Percent Purity 98.84%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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