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  5. Tocris Bioscience™ Pyridone 6

Tocris Bioscience™ Pyridone 6
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Product Code. 18736049
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18736049 10 mg 10mg
18718876 50 mg 50mg
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Product Code. 18736049 Supplier Tocris Bioscience™ Supplier No. 6577/10

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Description

Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable

Pyridone 6 is a potent pan-JAK inhibitor; ATP-competitive inhibitor of JAK 1/2/3 and Tyk2 (IC50 values are 1, 5, 15 and 1 nM, respectively). Inhibits other kinases tested at 130 nM to >10 μM. Inhibits IL-2- and IL-4-dependent proliferation of CTLL cells and blocks STAT5 phosphorylation. Also inhibits Th1 and Th2 development, and promotes Th17 differentiation from naive T cells. When used in combination with Retinoic acid, LY 294002 and CCG 1423, it induces intermediate mesoderm differentiation from ESCs. Inhibits growth of primary myeloma cells grown in the presence of bone marrow stromal cells. Cell-permeable.
TRUSTED_SUSTAINABILITY

Specifications

Synonym JAK inhibitor I
Quantity 10 mg
Molecular Formula C18H16FN3O
Formula Weight 309.34
Product Type Inhibitor
Purity 98%
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