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  4. ACROBiosystems Human IL-17A&IL-17F Heterodimer Protein, His Tag&Strep II Tag

ACROBiosystems Human IL-17A&IL-17F Heterodimer Protein, His Tag&Strep II Tag

Product Code. 16417769
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Quantity:
1 mg
100 μg
20 μg
Unit Size:
100µg
1mg
20µg

Product Code. 16417769

Brand: ACROBiosystems ILFH52WF1mg

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Description

Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Human IL-17A&IL-17F Heterodimer Protein, His Tag&Strep II Tag, produced by co-expression of IL-17A and IL-17F, has a calculated MW of 17.0 kDa (IL-17A) and 18.4 kDa (IL-17F). Subunit IL-17A is fused with a polyhistidine tag at the N-terminus and subunit I

Specifications

Accession Number NP_002181.1 (IL-17 A) and NP_443104.1 (IL-17 F)
Molecular Weight (g/mol) 17.0 kDa (IL-17 A) and 18.4 kDa (IL-17 F)
Quantity 1 mg
Source Human IL-17 A&IL-17; F Heterodimer Protein, His Tag&Strep; II Tag (ILF-H52WF) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Ala 155 (IL-17 A) and Arg 31 - Gln 163 (IL-17 F) (Accession # Q16552-1 (IL-17 A) and Q96PD4-1 (IL-17 F)). Two sequential affinity purification steps were used to ensure exact 1:1 molar ratio of IL17A&IL17F; heterodimer.
Immunogen Gly 24 - Ala 155 (IL-17 A) and Arg 31 - Gln 163 (IL-17 F)
Storage Requirements -20°C
Gene Alias IL-17 A,Interleukin-17 A,CTLA-8,IL-17,IL-17 F,Interleukin-17 F,Cytokine ML-1
Common Name IL-17 A and IL-17 F
Conjugate Unconjugated
Species Human
Protein Tag His Tag and Strep Tag
Buffer PBS, pH7.4
Endotoxin Level Less than 1.0 EU / μg by the LAL method.
Expression System HEK293
Form Powder
Protein Subtype Cytokines and Growth Factors
Purity or Quality Grade >95% as determined by reduced SDS-PAGE
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