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  5. Tocris Bioscience™ Pyr 10

Tocris Bioscience™ Pyr 10
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Product Code. 18768946
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18768946

Brand: Tocris Bioscience™ 6941/50

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Description

Selective TRPC3 inhibitor

Pyr 10 is a TRPC3 (transient receptor potential canonical 3) channel inhibitor (IC50 = 0.72 μM for TRPC3 mediated calcium entry in vitro), which displays approximately 18-fold selectivity for TRPC3-mediated receptor operated calcium entry (ROCE) over STIM1/Orai1-mediated store operated calcium entry (SOCE). Pyr 10 inhibits NFATc3 activation and inhibits proliferation of rat ventricular cardiac fibroblasts.
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Specifications

Chemical Name or Material N-[4-[3,5-bis(Trifluoromethyl)-1 H-pyrazol-1-yl]phenyl]-4-methylbenzenesulfonamide
CAS 1315323-00-2
Quantity 50 mg
Target TRPC Channel Blockers
Molecular Formula C18H13F6N3O2S
Purity 0.98
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