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Invitrogen™ PXR (SXR) Ligand Binding Domain Protein, GST Tag Recombinant Protein

Product Code. 10296403
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Quantity:
50 μg
Unit Size:
Each
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Product Code. 10296403

Brand: Invitrogen™ PV4841

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Description

Recombinant Protein

Pregnane X Receptor (Steroid and Xenobiotic Receptor), Ligand Binding Domain (PXR (SXR)-LBD) is a 64.7 kDa recombinant human protein (amino acids 111-434) expressed as a GST fusion protein in baculovirus-infected insect cells. PXR (SXR)-LBD was expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator recruitment or displacement studies. Protein Form: Recombinant, Ligand Binding Domain

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number O75469
Concentration See Label
For Use With (Application) Ligand Binding Assay
Formulation proprietary buffer with no preservative
Gene ID (Entrez) 8856
Name PXR (SXR) Ligand Binding Domain Protein, GST Tag
Quantity 50 μg
Regulatory Status RUO - research use only
Gene Alias BXR; mPXR; Nr1i2; Nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1, group 1, member 2; nuclear receptor subfamily 1, group I, member 2; ONR 1; ONR1; orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; PAR; PAR 1; PAR 2; PAR q; PAR1; PAR2; PARq; pregnane x nuclear receptor variant 2; Pregnane x receptor; pregnane x receptor (nuclear receptor sub family 1, group I, member 2); PRR; PXR; PXR0.1; PXR0.2; PXR1; SAR; Steroid and xenobiotic receptor; SXR
Common Name PXR
Protein Length 111-434
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag GST-tag
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Expression System Baculovirus
Form Liquid
Protein Subtype Hormone Receptors
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