Puromycin dihydrochloride, 98%

Product Code. 15493889

Brand: Thermo Scientific Alfa Aesar J61278.MC

Description

Puromycin dihydrochloride hydrate, CAS # 58-58-2, is an aminoglycoside showing antibiotic, anti-neoplastic, and anti-protozoal activities. This compound also has the ability to inhibit protein synthesis. | CAS: 58-58-2 | C22H31Cl2N7O5 | 544.43 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Suitable for battery materials development.

General Information

• Puromycin dihydrochloride hydrate is the hydrochloride salt form of puromycin and is an aminoglycoside with antibiotic activity isolated from the Streptomyces alboniger
• Puromycin dihydrochloride hydrate is a protein synthesis inhibitor that causes premature chain termination by acting as an analog of the 3’-terminal ends of aminoacyl-tRNA, inhibiting protein synthesis

Applications

• This compound shows anti-microbial, anti-protozoal, anti-trypanosomal, and anti-neoplastic activities and is also used as an antibiotic in cell culture
• It also reveals anti-tumor activity in studies on brain cancer cells
• This compound has been used to study transcriptional regulatory mechanisms that control the sequential and coordinate expression of genes during cell differentiation
• It is active against gram-positive microorganisms, less active against acid-fast bacilli and gram-negative microorganisms. Puromycin can prevent growth of bacteria, protozoa, algae, and mammalian cells in in vitro studies.

Specifications

Chemical Identifiers

• CAS: 58-58-2
• Molecular Formula: C22H31Cl2N7O5
• Molecular Weight (g/mol): 544.43
• MDL Number: MFCD00150080
• InChI Key: MKSVFGKWZLUTTO-MLYJQVMKNA-N
• PubChem CID: 131632508
• SMILES: Cl.Cl.COC1=CC=C(C[C@H](N)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C(N=CN=C23)N(C)C)C=C1

• Type: Puromycin Dihydrochloride
• Physical Form: Powder
• Melting Point: 168°C to 170°C
• Color: White
• Quantity: 100 mg
• Beilstein: 3853613
• Merck Index: 14,7943
• Solubility Information: Soluble in water
• IUPAC Name: (2S)-2-amino-N-[(2S,3S,4S,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide;dihydrochloride
• Formula Weight: 544.44
• Percent Purity: 99%
• Chemical Name or Material: Puromycin dihydrochloride

Sicherheit und Handhabung

Produktidentifikator

• Puromycin dihydrochloride

Signalwort

• Warning

Gefahrenkategorie

• Acute toxicity Category 4

Gefahrenhinweis

• H302-Harmful if swallowed.

Sicherheitshinweis

• P264-Wash face, hands, and anyexposed skin thoroughly after handling.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P312-Call a POISON CENTER/doctor/if you feel unwell.

Ergänzende Informationen

• MIXTURE LIST-Contains : (S)-3-[[2-Amino-3-(4-methoxyphenyl)-1-oxo propyl]amino]-3-deoxy-N,N-dimethyladenosine dihydrochlorid

Sicherheitsdatenblatt (SDS)

RUO – Research Use Only