STEMCELL Technologies Puromycin (Dihydrochloride)

Product Code.	Quantity	unitSize
17110212	500 mg	500mg
17100212	50 mg	50mg

Product Code. 17110212

Brand: STEMCELL Technologies 73344

Descripción

Antibiotic; Protein synthesis inhibitor

• Puromycin is an aminonucleoside antibiotic, derived from Streptomyces alboniger, which acts as a protein synthesis inhibitor
• It binds to the target ribosome site A, where it is transferred to the growing polypeptide chain causing premature chain termination (Lührmann et al.; Rodriguez-Fonseca et al.; Azzam & Algranati)
• A biologically inactive form is generated when puromycin is N-acetylated by puromycin-N-acetyltransferase, allowing this gene to be used as a selective resistance marker (Vara et al.) 1985)
• Selects for cells expressing puromycin-N-acetyltransferase resistance gene as a research tool (de la Luna & Ortín; Iwaki et al.)
• Useful in CRISPR/Cas9 mammalian gene editing by selecting for successful Cas9-induced knock-in with puromycin resistance gene (Park et al.)
• Possesses anti-tumor activity when tested against numerous cell lines (Foley & Eagle)

Especificaciones

• CAS: 58-58-2
• Quantity: 500 mg
• Percent Purity: ≥98%