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Invitrogen™ PUMA alpha Polyclonal Antibody

Product Code. 12818032
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12818032 100 μg 100µg
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Product Code. 12818032 Supplier Invitrogen™ Supplier No. PA520008

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Description

Rabbit Polyclonal Antibody

The PA5-20008 immunogen is located within the first 50 amino acids of PUMA. The immunogenic sequence is identical between the A and B forms of PUMA. In Western blot applications, this antibody detects a band at ~23kDa. A suggested positive control is K562 cell lysate. PA5-20008 can be used with blocking peptide PEP-0128. Predicted species reactivity based on immunogen sequence: Rat: (79%), Mouse: (79%).

PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PUMA alpha
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene BBC3
Gene Accession No. Q80ZG6, Q9BXH1
Gene Alias BBC3; BCL2 binding component 3; Bcl-2 binding component 3; bcl-2-binding component 3; Bcl-2-binding component 3, isoforms 1/2; Bcl-2-binding component 3, isoforms 3/4; BH3-only; FLJ42994; JFY1; JFY-1; p53 up-regulated modulator of apoptosis; PUMA; PUMA/JFY1
Gene Symbols BBC3
Host Species Rabbit
Immunogen A 14 amino acid peptide near the amino terminus of human PUMA isoform 1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27113, 317673
Target Species Human, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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