Invitrogen™ PUM1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5102944

Product Code. 16689394

Description

Antibody detects endogenous levels of total PUM1.

PUM1 (pumilio homolog 1) is a sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. It is a member of the PUF family comprised of evolutionarily conserved RNA-binding proteins. PUM1 binds to an RNA consensus sequence, the Pumilio Response Element (PRE), and 5'-UGUANAUA-3' that is related to the Nanos Response Element (NRE). PUM1 mediates post-transcriptonal repression of transcripts via different mechanisms - acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Mutations to the gene can result in spinocerebellar ataxia 47.

Specifications

• Antigen: PUM1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PUM1
• Gene Alias: AA517475; HsPUM; KIAA0099; mKIAA0099; PUM1; PUMH; PUMH1; pumilio 1; pumilio homolog 1; pumilio RNA binding family member 1; pumilio RNA-binding family member 1; pumilio-1; PUML1; Pumm
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 80912, 9698
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q14671, Q80U78
• Gene Symbols: PUM1
• Immunogen: A synthesized peptide derived from human PUM1(Accession Q14671), corresponding to amino acid residues E223-G273.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG