Invitrogen™ PUF60 Monoclonal Antibody (GT917)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA531497

Product Code. 16374934

Description

Keep as concentrated solution. Positive Control: 293T, A431, HeLa, HepG2, mouse brain, rat brain. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

PUF60 encodes a protein that is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene.

Specifications

• Antigen: PUF60
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: Q3UEB3, Q9UHX1, Q9WV25
• Gene Symbols: Puf60
• Immunogen: Recombinant protein encompassing a sequence within the center region of human PUF60. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: GT917
• Conjugate: Unconjugated
• Gene: Puf60
• Gene Alias: 2410104I19Rik; 2810454F19Rik; 60 kDa poly(U)-binding-splicing factor; FBP interacting repressor; FBP-interacting repressor; FIR; FLJ31379; FUSE-binding protein-interacting repressor; LOW QUALITY PROTEIN: poly(U)-binding-splicing factor PUF60; poly(U) binding splicing factor 60; poly(U) binding splicing factor 60KDa; poly(U)-binding-splicing factor PUF60; poly-U binding splicing factor 60; poly-U binding splicing factor 60K; poly-U binding splicing factor 60KDa; PUF60; pyrimidine tract binding splicing factor; RNA-binding protein Siah-BP; Ro ribonucleoprotein-binding protein 1; Ro-binding protein 1; RoBP1; ROBPI; Siah binding protein 1; siah binding protein 1; FBP interacting repressor; pyrimidine tract binding splicing factor; Ro ribonucleoprotein-binding protein 1; siah-binding protein 1; SIAHBP1; Siah-BP1; similar to fuse-binding protein-interacting repressor isoform a; VRJS
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 22827, 67959, 84401
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid