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PU.1/Spi-1 Antibody (PU1/2146) - Azide and BSA Free, Novus Biologicals™

Product Code. 18346761 Shop All Bio Techne Products
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100 μg
Unit Size:
100µg
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18346761 100 μg 100µg
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Product Code. 18346761 Supplier Novus Biologicals Supplier No. NBP275766

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Description

Mouse Monoclonal Antibody

PU.1/Spi-1 Monoclonal specifically detects PU.1/Spi-1 in Human samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Protein Array.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PU.1/Spi-1
Applications Western Blot, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone PU1/2146
Concentration 0.2 mg/ml
Conjugate Unconjugated
Dilution Western Blot 0.5-1 ug/ml, Immunohistochemistry-Paraffin 1-2 ug/ml
Formulation 10 mM PBS with No Preservative
Gene Accession No. P17947
Gene Alias hematopoietic transcription factor PU.1, OF, PU.1, SFPI131 kDa transforming protein, SPI-1, SPI-1 proto-oncogene, SPI-A, spleen focus forming virus (SFFV) proviral integration oncogene spi1,31 kDa-transforming protein, transcription factor PU.1
Gene Symbols SPI1
Host Species Mouse
Immunogen Recombinant fragment (around aa 16-170) of human PU.1/Spi-1 protein (Exact sequence is proprietary) (Uniprot: P17947 )
Molecular Weight of Antigen 40 kDa
Purification Method Protein A or G purified
Quantity 100 μg
Research Discipline Innate Immunity
Primary or Secondary Primary
Gene ID (Entrez) 6688.0
Test Specificity PU.1 is a member of the ETS family of transcription factors and is important for normal B-cell development. It is expressed in the myeloid lineage and in immature as well as mature B-lymphocytes, with the exception of plasma cells. PU.1 is expressed in germinal center B-cells and mantle B-cells. Various lymphomas are also positive for this marker. It is essential during early B-cell differentiation. The absence of PU.1 results in total block of B-cell development at the pre-pro stage. PU.1 plays a key role in normal myeloid differentiation, and regulates the expression of immunoglobulin and other genes that are important for B-cell development.
Target Species Human
Content And Storage Store at 4°C.
Form Purified
Isotype IgG2b κ
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