Invitrogen™ PTRF Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA584948

Product Code. 16371895

Description

Immunogen sequence: VSVNVKTVRG SLERQAGQIK KLEVNEAELL RRRNFKVMIY QDEVKLPAKL SISKSLKESE ALPEKEGEEL GEGERPEEDA AALELSSD Highest antigen sequence indentity to the following orthologs: Rat - 97%, Mouse - 94%.

The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts, regulating rRNA transcription by promoting the dissociation of transcription complexes and the re-initiation of polymerase I on nascent rRNA transcripts. PTRF also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins, translocating from caveolae to the cytoplasm after insulin stimulation. PTRF is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.

Specifications

• Antigen: PTRF
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CAVIN1
• Gene Alias: 2310075E07Rik; AW546441; caveolae associated protein 1; caveolae-associated protein 1; CAVIN; CAVIN1; cavin-1; Cav-p60; CGL4; FKSG13; FLJ90031; Polymerase I and transcript release factor; PTRF; ptrf {ECO:0000312; RGD:1307685}; RNA polymerase I and transcript release factor; TTF-I interacting peptide 12
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 284119
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6NZI2
• Gene Symbols: CAVIN1
• Immunogen: Recombinant protein corresponding to Human CAVIN1. Recombinant protein control fragment (Product #RP-107984).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG