Invitrogen™ PTPRCAP Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA560487

Product Code. 15738321

Description

Immunogen sequence: DTDYDHVADG GLQADPGEGE QQCGEASSPE QVPVRAEEAR DSDTEGDLVL GSPGPASA Highest antigen sequence identity to the following orthologs: Mouse - 33%, Rat - 34%.

MSK-1 is a mitogen and stress activated protein kinase-1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK-1 can be activated by ERK1/2 and SAPK2 /p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG-14 in response to mitogen and stress. Similar to RSK, MSK-1 contains two kinase domains (N-term and a C-term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK-1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C-terminal kinase domain of MSK-1 which is essential for the catalytic activity of the N-terminal kinase domain.

Specifications

• Antigen: PTPRCAP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PTPRCAP
• Gene Alias: AI605264; CD45 associated protein; CD-45-AP; CD45-AP; CD45-associated protein; LPAP; LSM-1; Lymphocyte phosphatase-associated phosphoprotein; protein tyrosine phosphatase receptor type C-associated protein; protein tyrosine phosphatase, receptor type C associated protein; protein tyrosine phosphatase, receptor type, C polypeptide-associated protein; protein tyrosine phosphatase, receptor type, C-associated protein; Ptprcap; PTPRC-associated protein
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5790
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q14761
• Gene Symbols: PTPRCAP
• Immunogen: Recombinant protein corresponding to Human PTPRCAP. Recombinant protein control fragment (Product #RP-100004).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG