Invitrogen™ PTGIS Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA553132

Product Code. 15711081

Description

Immunogen sequence: LTLYGIEALP RTHESQAQDR VHSADVFHTF RQLDRLLPKL ARGSLSVGDK DHMCSVKSRL WKLLSPARLA RRAHRSKWLE SYLLHLEEMG VSEEMQARAL VLQLWATQGN MGPAAFWLLL FLLKNPEALA AVRGELESIL WQAEQ Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 85%.

CYP8A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.

Specifications

• Antigen: PTGIS
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PTGIS
• Gene Alias: Cyp8; CYP8A1; cytochrome P450 8A1; cytochrome P450, family 8, subfamily A, polypeptide 1; hydroperoxy icosatetraenoate dehydratase; LOW QUALITY PROTEIN: prostacyclin synthase; MGC126858; MGC126860; PGIS; Prostacyclin synthase; prostaglandin I2 (prostacyclin) synthase; prostaglandin I2 (prostacyclin) synthase like; prostaglandin I2 synthase; PTGI; ptgis; ptgisl
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5740
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q16647
• Gene Symbols: PTGIS
• Immunogen: Recombinant protein corresponding to Human PTGIS. Recombinant protein control fragment (Product #RP-90174).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG