Invitrogen™ PSPN Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA550530

Product Code. 15694455

Description

The antibody detects endogenous levels of total Persephin protein.

Persephin is a disulfide-linked, homodimeric, neurotrophic factor structurally related to GDNF, artemin, and neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFR alpha (alpha1-alpha4) receptors. The GFRalpha4 was first identified in chicken, and was later shown to be the preferential binding subunit for persephin. Persephin promotes the survival of ventral midbrain dopaminergic neurons and motor neurons after sciatic nerve oxotomy, and, like GDNF, promotes ureteric bud branching. However, in contrast to GDNF and neurturin, persephin does not support the survival of peripheral neurons.

Specifications

• Antigen: PSPN
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PSPN
• Gene Alias: Persephin; PSP; Pspn
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5623
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.8 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: O60542
• Gene Symbols: PSPN
• Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human persephin.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG