Invitrogen™ PSMD14 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5107010

Product Code. 17106823

Description

Sequence homology: Cow: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 100%; Zebrafish: 100%.

The 26S proteasome is responsible for most intracellular proteolysis in eukaryotes. POH1 (also known as Rpn11 in yeast) subunit of the 19S complex is responsible for substrate deubiquitination during proteasomal degradation. POH1 appears to be a Zn21-dependent protease, unlike all other known deubiquitinating enzymes (DUBs) that are cysteine proteases. POH1 was first identified as the human functional homolog of the S. pombe pad1 gene, which confers moderate resistance to chemotherapeutic drugs, and also to ultraviolet light when transiently overproduced in mammalian cells. Poh1-induced drug resistance is mediated through AP-1 transcription factors.

Specifications

• Antigen: PSMD14
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PSMD14
• Gene Alias: 2610312C03Rik; 26S proteasome non-ATPase regulatory subunit 14; 26S proteasome non-ATPase subunit; 26S proteasome regulatory subunit rpn11; 26S proteasome-associated pad1 homolog; 26S proteasome-associated PAD1 homolog 1; 3200001M20Rik; AA986732; MAD1; PAD1; POH1; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14; proteasome 26S subunit, non-ATPase 14; Psmd14; rpm11; RPN11; testis tissue sperm-binding protein Li 69n
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10213
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
• Gene Accession No.: O00487
• Gene Symbols: PSMD14
• Immunogen: Synthetic peptide directed towards the C-terminal region of human PSMD14.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG