Invitrogen™ PRSS27 Polyclonal Antibody

Goat Polyclonal Antibody

Brand:  Invitrogen™ PA547235

Product Code. 15597722

Description

In direct ELISAs, approximately 15% cross-reactivity with recombinant human Marapsin is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

PRSS27, also known as Marapsin, is a gene located on chromosome 16p13.3 that encodes a serine protease enzyme. This protein is part of the trypsin-like serine protease family, which is characterized by a catalytic triad essential for proteolytic activity. PRSS27 is primarily expressed in the epidermis and other epithelial tissues, such as the salivary glands and pancreas. It plays a role in various physiological processes, including digestion, inflammation, and immune response regulation. In the skin, PRSS27 is involved in keratinocyte differentiation and the maintenance of skin barrier function. Dysregulation or altered expression of PRSS27 has been associated with inflammatory skin conditions, such as psoriasis, where it may influence the inflammatory cascade and contribute to disease pathogenesis. Research into PRSS27 continues to explore its potential role in epithelial homeostasis and as a therapeutic target for skin-related and other inflammatory disorders.

Specifications

• Antigen: PRSS27
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRSS27
• Gene Alias: CAP-2; CAPH2; channel-activating protease 2; channel-activating protease 2-like protein; EC 3.4.21; EC 3.4.21.4; EC 3.4.21.43; marapsin; Mpn; MPNMarapsin; Pancreasin; protease, serine 27; PRSS27; Serine protease 27; UNQ1884/PRO4327
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 213171
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunoprecipitation, Neutralization, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q8BJR6
• Gene Symbols: PRSS27
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Marapsin/Pancreasin Ala23-Thr290.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG