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Invitrogen™ PRR5L Polyclonal Antibody

Product Code. 12849272
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Quantity:
100 μg
Unit Size:
100µg
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12849272 100 μg 100µg
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Product Code. 12849272 Supplier Invitrogen™ Supplier No. PA521129

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Description

Rabbit Polyclonal Antibody

A suggested positive control is NIH-3T3 cell lysate. PA5-21129 can be used with blocking peptide PEP-1243.

Proline-rich protein 5-like (PRR5L), also known as Protor-2, is structurally similar to PRR5 and also binds to the mTOR complex 2 (mTORC2). PRR5L is not required for mTORC2 integrity or kinase activity, but dissociates from mTORC2 upon knockdown of tuberous sclerosis complex 1 (TSC1) and TSC2. Knockdown of PRR5L reduced apoptosis in mTORC2 deficient cells as well as cells where mTOR was active, suggesting that mTORC2-dissociated PRR5L may promote apoptosis, and thus play a role in the balance between cell growth and cell death.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PRR5L
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene PRR5L
Gene Accession No. A2AVJ5, Q6MZQ0
Gene Alias 2600010E01Rik; 4833411O04Rik; proline rich 5 like; proline-rich protein 5-like; Protein observed with Rictor-2; PROTOR2; protor-2; Prr5l
Gene Symbols PRR5L
Host Species Rabbit
Immunogen A 17 amino acid peptide near the center of human PRR5L.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 72446, 79899
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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