Invitrogen™ PRPS2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA566936

Product Code. 15969614

Description

Immunogen sequence: GAKRYHAGYTL QISPSADWF Highest antigen sequence identity to the following orthologs - mouse 40%, rat 45%.

The Phosphoribosyl Pyrophosphate Synthetase 2 (PRPS2) gene plays a critical role in cellular metabolism by encoding an enzyme that conducts a key reaction linking central carbon metabolism and nucleotide production, essential for various biological functions. Structurally, PRPS2 shares a high sequence identity with PRPS1, making it less sensitive to allosteric inhibition and particularly significant in certain oncology contexts due to its upregulation at the translational level in some cancers. The enzyme encoded by PRPS2 is pivotal in coupling protein and nucleotide biosynthesis, aided by a unique cis-regulatory element in its 5' UTR, which is influenced by oncogenic pathways. This gene manifests a tissue-specific expression profile, predominantly in proliferative tissues such as the thymus, lung, and small intestine, highlighting its significance in cell growth and proliferation. The evolutionary origins of PRPS2, along with its functional diversification into multiple PRPS genes in eukaryotes, underscore its indispensable role in cellular physiology and pathology.

Specifications

• Antigen: PRPS2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRPS2
• Gene Alias: 2610101M19Rik; AA589463; AI464149; Phophoribosylpyrophosphate synthetase, subunit II; phosphoribosyl pyrophosphate synthase II; phosphoribosyl pyrophosphate synthetase 2; phosphoribosyl pyrophosphate synthetase II; PPRibP; PPRibP synthetase; Prps2; Prps-2; PRSII; PRS-II; ribose-phosphate diphosphokinase 2; ribose-phosphate pyrophosphokinase 2; testicular secretory protein Li 41
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5634
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P11908
• Gene Symbols: PRPS2
• Immunogen: Recombinant Human PRPS2. Recombinant protein control fragment (Product #RP-105432).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG