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PROTAC Sirt2 Degrader-1, MedChemExpress

Product Code. 16453878
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Quantity:
5 mg
10 mg
Unit Size:
10mg
5mg
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Product Code. 16453878

Brand: Medchem Express HY103636

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Description

MedChemExpress PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM).

PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM).

Specifications

Chemical Name or Material PROTAC Sirt2 Degrader-1
CAS 2098487-75-1
Color Off-White
Purity Grade Notes Research
Molecular Formula C40H40N10O8S2
Quantity 10 mg
Solubility Information DMSO : ≥ 100 mg/mL (117.24 mM)
SMILES O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(NCCCCN4C=C(COC5=CC(CC6=CN=C(NC(CSC7=NC(C)=CC(C)=N7)=O)S6)=CC=C5)N=N4)=O
Molecular Weight (g/mol) 852.94
Formula Weight 852.94
Percent Purity 98.5%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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