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STEMCELL Technologies Prostaglandin E2

Prostanoid pathway activator; Activates prostaglandin receptors EP1, EP2, EP3 and EP4

Brand:  STEMCELL Technologies 72192

Code : Z1

Additional Details : Weight : 0.01000kg

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Product Code. 15692517

  • £107.73 / 1mg
Estimated Shipment: 06-03-2024
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Description

Description

  • Prostaglandin E2 (PGE2) is the most biologically active and well-studied prostaglandin
  • It binds with very high affinity to the EP1, EP2, EP3, and EP4 receptors (Ki = 9.1, 4.9, 0.33, 0.79 nM respectively)
  • (Abramovitz et al.), Bos et al.)
  • Required for the development of hematopoietic stem cells (HSCs) in mice and zebrafish (North et al.)
  • Improves engraftment of mouse HSCs, possibly through increasing homing, survival, and/or self-renewal (Hoggatt et al. 2009, Hoggatt et al.) 2013, North et al.)
  • Promotes differentiation of hematopoietic progenitor cells from mouse, macaque, and human embryonic stem cells (Gori et al.), North et al.), Woods et al.)
  • Promotes differentiation of myeloid-derived suppressor cells from hematopoietic progenitors (Sinha et al.)
  • Promotes differentiation of Th17 cells from naïve T-cells (Boniface et al.)
Specifications

Specifications

363-24-6
1 mg
≥98%
Dinoprostone; PGE2
C20H32O5
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