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STEMCELL Technologies Prostaglandin E2
Prostanoid pathway activator; Activates prostaglandin receptors EP1, EP2, EP3 and EP4
Brand: STEMCELL Technologies 72192
Code : Z1
Additional Details : Weight : 0.01000kg
Description
- Prostaglandin E2 (PGE2) is the most biologically active and well-studied prostaglandin
- It binds with very high affinity to the EP1, EP2, EP3, and EP4 receptors (Ki = 9.1, 4.9, 0.33, 0.79 nM respectively)
- (Abramovitz et al.), Bos et al.)
- Required for the development of hematopoietic stem cells (HSCs) in mice and zebrafish (North et al.)
- Improves engraftment of mouse HSCs, possibly through increasing homing, survival, and/or self-renewal (Hoggatt et al. 2009, Hoggatt et al.) 2013, North et al.)
- Promotes differentiation of hematopoietic progenitor cells from mouse, macaque, and human embryonic stem cells (Gori et al.), North et al.), Woods et al.)
- Promotes differentiation of myeloid-derived suppressor cells from hematopoietic progenitors (Sinha et al.)
- Promotes differentiation of Th17 cells from naïve T-cells (Boniface et al.)
Specifications
363-24-6 | |
1 mg | |
≥98% |
Dinoprostone; PGE2 | |
C20H32O5 |