Prosapip2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA520814

Product Code. 12828992

Description

A suggested positive control is rat liver tissue lysate. PA5-20814 can be used with blocking peptide PEP-0928.

Prosapip2 (TBKBP1) is essential for signal transduction during viral infection thus plays a major role in the TNF/NF-kappa-B pathway. It is an adaptor protein that constitutively binds TBK1 (TANK-binding kinase) and IKBKE and may play a role in antiviral innate immunity. Prosapip2 is a 615 amino acid adaptor protein belonging to the fibrillar collagen family, consisting of trimers of identical alpha 1 chains which are linked to each other by interchain disulfide bonds. It has a ubiquitous expression with highest levels in ovary, followed by the neuronal system. Prosapip2 binds to TBK1 and helps in the activation of IRF3 which controls the expression of antiviral genes during infection. Recent studies show that Prosapip2 is an interaction partner of ProSAP2/Shank3 and actin, suggesting a role as a linker molecule between postsynaptic density and the cytoskeleton.

Specifications

• Antigen: Prosapip2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TBKBP1
• Gene Alias: 3110043L15Rik; KIAA0775; Prosapip2; Protein ProSAPiP2; RGD:631328}; Similar to NAP1 TBK1 adapter; Sintbad; TANK-binding kinase 1-binding protein 1; TBK1 binding protein 1; TBK1-binding protein 1; Tbkbp1; tbkbp1 {ECO:0000312
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 266764, 73174, 9755
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: A2A9T0, A7MCY6, Q6DG50
• Gene Symbols: TBKBP1
• Immunogen: A 16 amino acid peptide from near the carboxy terminus of human Prosapip2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG