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Invitrogen™ Prosapip2 Polyclonal Antibody

Product Code. 12828992
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Quantity:
100 μg
Unit Size:
100µg
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12828992 100 μg 100µg
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Product Code. 12828992 Supplier Invitrogen™ Supplier No. PA520814

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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat liver tissue lysate. PA5-20814 can be used with blocking peptide PEP-0928.

Prosapip2 (TBKBP1) is essential for signal transduction during viral infection thus plays a major role in the TNF/NF-kappa-B pathway. It is an adaptor protein that constitutively binds TBK1 (TANK-binding kinase) and IKBKE and may play a role in antiviral innate immunity. Prosapip2 is a 615 amino acid adaptor protein belonging to the fibrillar collagen family, consisting of trimers of identical alpha 1 chains which are linked to each other by interchain disulfide bonds. It has a ubiquitous expression with highest levels in ovary, followed by the neuronal system. Prosapip2 binds to TBK1 and helps in the activation of IRF3 which controls the expression of antiviral genes during infection. Recent studies show that Prosapip2 is an interaction partner of ProSAP2/Shank3 and actin, suggesting a role as a linker molecule between postsynaptic density and the cytoskeleton.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Prosapip2
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TBKBP1
Gene Accession No. A2A9T0, A7MCY6, Q6DG50
Gene Alias 3110043L15Rik; KIAA0775; Prosapip2; Protein ProSAPiP2; RGD:631328}; Similar to NAP1 TBK1 adapter; Sintbad; TANK-binding kinase 1-binding protein 1; TBK1 binding protein 1; TBK1-binding protein 1; Tbkbp1; tbkbp1 {ECO:0000312
Gene Symbols TBKBP1
Host Species Rabbit
Immunogen A 16 amino acid peptide from near the carboxy terminus of human Prosapip2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 266764, 73174, 9755
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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