Progesterone, 98%, Thermo Scientific Chemicals

Progesterone, CAS # 57-83-0, is a naturally occurring hormone required for maintenance of the uterine endothelium and suppression of estrogens.

Brand:  Thermo Scientific Acros 225650050

Product Code. 10368310

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Progesterone is a sex hormone required for suppression of estrogen signaling and is also involved in transcriptional activation

• Progesterone maintains the uterine endothelium and sustains pregnancy through suppression of muscle contractility

Applications

• Progesterone signaling is relevant to the study of breast cancer

Literature References

Kim, O.; Park, E.Y.; Kwon, S.Y.; Shin, S.; Emerson, R.E.; Shin, Y.H.; DeMayo, F.J.; Lydon, J.P.; Coffey, D.M.; Hawkins, S.M.; Quilliam, L.A.; Cheon, D.J.; Fernández, F.M.; Nephew, K.P.; Karpf, A.R.; Widschwendter, M.; Sood, A.K.; Bast, R.C. Jr.; Godwin, A.K.; Miller, K.D.; Cho, C.H.; Kim, J. Targeting progesterone signaling prevents metastatic ovarian cancer. Proc Natl Acad Sci U S A. 2020, 117(50), 31993-32004.

Jain, V.; McDonald, S.D.; Mundle, W.R.; Farine, D. Guideline No. 398: Progesterone for Prevention of Spontaneous Preterm Birth. J Obstet Gynaecol Can. 2020, 42(6), 806-812.

Chemical Identifiers

• CAS: 57-83-0
• Molecular Weight (g/mol): 314.46
• InChI Key: RJKFOVLPORLFTN-LEKSSAKUSA-N
• PubChem CID: 5994
• IUPAC Name: (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

• Molecular Formula: C₂₁H₃₀O₂
• MDL Number: MFCD00003658
• Synonym: progesterone, agolutin, luteohormone, pregn-4-ene-3,20-dione, crinone, 4-pregnene-3,20-dione, corpus luteum hormone, progestin, syngesterone, utrogestan
• ChEBI: CHEBI:17026
• SMILES: CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

Specifications

• CAS: 57-83-0
• Color: Brown-Yellow to Yellow
• Infrared Spectrum: Authentic
• Packaging: Glass bottle
• MDL Number: MFCD00003658
• Merck Index: 15, 7889
• Specific Rotation: + 190
• Solubility Information: Solubility in water: insoluble. Other solubilities: soluble in alcohol,acetone,dioxane,conc. h2so4
• SMILES: CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
• Molecular Weight (g/mol): 314.46
• ChEBI: CHEBI:17026
• Percent Purity: 98%
• Chemical Name or Material: Progesterone

• Melting Point: 126°C to 131°C
• Loss on Drying: 0.5% max. (500 mg, 105°C, 2 hrs)
• Assay Percent Range: 97.5% min. (HPLC)
• Molecular Formula: C₂₁H₃₀O₂
• Quantity: 5 g
• Specific Rotation Condition: +190° (20°C c=1,ethanol)
• Synonym: progesterone, agolutin, luteohormone, pregn-4-ene-3,20-dione, crinone, 4-pregnene-3,20-dione, corpus luteum hormone, progestin, syngesterone, utrogestan
• InChI Key: RJKFOVLPORLFTN-LEKSSAKUSA-N
• IUPAC Name: (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• PubChem CID: 5994
• Formula Weight: 314.46
• Physical Form: Crystalline Powder, Crystals or Chunks

Safety and Handling

Product Identifier

• Progesterone

Signal Word

• Warning

Hazard Category

• Carcinogenicity Category 2

Hazard Statement

• H351-Suspected of causing cancer.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.