Invitrogen™ PRMT9 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA557845

Product Code. 15715741

Description

Immunogen sequence: HTKSLDIEIP KHIPERVSLV VTETVDAGLF GEGIVESLIH AWEHLLLQPK TKGESANCEK YGKVIPASAV IFGMAVECAE IRRHHRVGIK DIAGIHLPT Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 89%.

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.

Specifications

• Antigen: PRMT9
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRMT9
• Gene Alias: AI931714; Prmt10; PRMT9; protein arginine methyltransferase 10 (putative); protein arginine methyltransferase 9; Protein arginine N-methyltransferase 10; Protein arginine N-methyltransferase 9; putative protein arginine N-methyltransferase 10; putative protein arginine N-methyltransferase 9; RGD1306157
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 90826
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6P2P2
• Gene Symbols: PRMT9
• Immunogen: Recombinant protein corresponding to Human PRMT9. Recombinant protein control fragment (Product #RP-96723).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG