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  6. PRKAR1A Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

PRKAR1A Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16889884 Shop All Proteintech Products
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150 μL
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150µL
20µL
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16889884 150 μL 150µL
16899884 20 μL 20µL
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Product Code. 16889884 Supplier Proteintech Supplier No. 203581AP150UL

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Description

Rabbit Polyclonal Antibody

The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme, resulting in release of active catalytic subunits. Four different PKA regulatory subunits have been identified, designated Ia, Ib, IIa and IIb. The PKA Ia reg protein is a tissue-specific extinguisher that downregulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Functional null mutations in the gene that codes for PKA Ia reg cause Carney complex (CNC). CNC is an autosomal domit multiple neoplasia syndrome. CNC is associated with a variety of characterized symptoms such as cardiac and other myxomas, spotty skin pigmentation, endocrine tumors and psammomatous melanotic schwannomas.

Specifications

Antigen PRKAR1A
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.62 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene PRKAR1A
Gene Accession No. P09456, P10644, Q9DBC7
Gene Alias CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, PRKAR1A, Tissue specific extinguisher 1, TSE1
Gene Symbols Prkar1a
Host Species Rabbit
Immunogen PRKAR1A Fusion Protein Ag14216
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19084, 25725, 5573
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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