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  6. Invitrogen™ Presenilin 1 Recombinant Rabbit Monoclonal Antibody (K01_3L61)

Invitrogen™ Presenilin 1 Recombinant Rabbit Monoclonal Antibody (K01_3L61)

Product Code. 30827850
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30828499 100 μL
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Product Code. 30827850 Supplier Invitrogen™ Supplier No. MA564536

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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: EGDPEAQRRV SKNSKYNAES TERESQDTVA ENDDGGFSEE WEAQRDSHLG PHRSTPESRA AVQELSSSIL AGEDPEERGV KLGLGDFIFY SVLVGKASAT A Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 85%, Pig - 84%, Cynomolgus monkey - 100%.

Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and -gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease. Multiple isoforms of presenilin1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Presenilin 1
Applications Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone K01_3L61
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 150mM NaCl, 0.05% BSA, 40% glycerol and 0.01% sodium azide; pH 7.4
Gene PSEN1
Gene Accession No. P49768
Gene Alias AD3; Ad3h; Alzheimer Disease 3; FAD; Minilin; presenilin 1; presenilin 1 (Alzheimer disease 3); presenilin1; presenilin-1; Presenilin-1 CTF subunit; Presenilin-1 CTF12; Presenilin-1 NTF subunit; Protein S182; PS1; PS-1; PS1-CTF12; PSEN1; Psnl1; S182; S182 protein; Senilin 1
Gene Symbols PSEN1
Host Species Rabbit
Immunogen A synthetic peptide of human Presenilin 1 (aa 300-400).
Purification Method Protein A/G
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5663
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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