Prednisolone, 99%, Thermo Scientific Chemicals

Description

Prednisolone, or metacortandralone, CAS # 50-24-8, is a synthetic glucocorticoid.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Prednisolone is a derivative of prednisone with an oxo to beta-hydroxy reduction at position 11

• Prednisolone binds cell surface receptors and is transported to the nucleus, where it binds certain nuclear receptors responsible for transcription of proinflammatory cytokines

Applications

• Prednisolone can be used for laboratory research on tumor growth and prevention

• Prednisolone may also be used for developmental and endocrine research, in vivo or in vitro

Specifications

Chemical Identifiers

• CAS: 50-24-8
• Molecular Formula: C₂₁H₂₈O₅
• Molecular Weight (g/mol): 360.44
• InChI Key: OIGNJSKKLXVSLS-VWUMJDOOSA-N
• Synonym: prednisolone, metacortandralone, hydroretrocortine, predonine, deltacortril, meticortelone, deltahydrocortisone, prenolone, hydroretrocortin, delta-cortef
• PubChem CID: 5755
• ChEBI: CHEBI:8378
• IUPAC Name: (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
• SMILES: CC12CC(C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C)O

• Melting Point: 240.0°C
• Assay Percent Range: 98.5% min. (HPLC)
• Packaging: Glass bottle
• Quantity: 1 g
• Merck Index: 15,7841
• Solubility Information: Solubility in water: slightly soluble. Other solubilities: soluble in methanol, dioxane, slightly soluble in acetone, chloroform,, ethylacetate
• Formula Weight: 360.44
• Percent Purity: 99%
• Chemical Name or Material: Prednisolone

Safety and Handling

Product Identifier

• Prednisolone

Signal Word

• Danger

Hazard Category

• Reproductive toxicity Category 1B

Hazard Statement

• H360D-May damage the unborn child.

Precautionary Statement

• P202-Do not handle until all safety precautions have been read and understood.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.

RUO – Research Use Only