Invitrogen™ PRDM2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5110216

Product Code. 17168143

Description

Immunogen sequence: MNQNTTEPVA ATETLAEVPE HVLRGLPEEV RLFPSAVDKT RIGVWATKPI LKGKKFGPFV GDKKKRSQVK NNVYMWEVYY PNLGWMCIDA TDPEKGNWLR YVNWACSGEE QNLFPLEINR AIYYKTLKPI APGEELLVWY NGEDNPEIAA AIEEERASAR SKRSSPKSRK GKKKSQ.

PRDM2, a member of nuclear/histone methyltransferase superfamily, consists of an N-terminal PR domain, an Rb-binding motif, 8 Kruppel-like zinc finger motifs, Nuclear hormone-receptor binding motif and a C-terminal PR-domain binding motif. Ubiquitously expressed in low levels, PRDM2 exists in 2 isoforms, a 280 kDa RIZ1 containing PR-domain and a 250 kDa truncated RIZ2 that lacks PR-domain. A tumor suppressor with a prominent role in cell growth and differentiation, PRDM2 binds to Retinoblastoma protein, estrogen receptor, GATA-3 and TPA-responsive element (MTE) of Heme-oxygenase-1 gene and influences pathogenesis of Retinoblastoma, transcriptional regulation during neuronal differentiation, transactivation of Heme-oxygenase-1 gene and specific effector of estrogen action. It is inactivated or altered due to mutations and hypermethylation in many types of human cancers suggesting a potential biomarker.

Specifications

• Antigen: PRDM2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRDM2
• Gene Alias: 4833427P12Rik; E330024L24Rik; G3b; GATA-3 binding protein G3B; GATA-3-binding protein G3B; Gm1033; Gm19732; HUMHOXY1; KMT8; lysine N-methyltransferase 8; MTBzf; MTB-ZF; MTE-binding protein; PR domain 2; PR domain containing 2, with ZNF domain; PR domain zinc finger protein 2; PR domain-containing protein 2; Prdm2; retinoblastoma interacting zinc finger protein; retinoblastoma protein-binding zinc finger protein; retinoblastoma protein-interacting zinc finger protein; RIZ; RIZ1; RIZ2; RP5-1177E19.1; zinc finger protein RIZ; zinc-finger DNA-binding protein; Znfpr1c1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 110593, 313678, 7799
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.17 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q13029, Q63755
• Gene Symbols: PRDM2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-176 of human PRDM2 (NP_0363632).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG