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PRDM16 Polyclonal Antibody, Invitrogen™

Goat Polyclonal Antibody

Brand:  Invitrogen PA5142015

Additional Details : Weight : 0.01000kg

Product Code. 17838382

  • £371.00 / 100µL
Estimated Shipment: 06-08-2024
to see stock.

Description

Description

Additional Information: This antibody is expected to recognise both reported isoforms. This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36, q21)-positive MDS/AML. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway. Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.
Specifications

Specifications

PRDM16
Polyclonal
Unconjugated
PRDM16
5730557K01Rik; CMD1LL; csp1; Histone-lysine N-methyltransferase PRDM16; Kiaa1675; line 27; LVNC8; MDS1/EVI1-like gene 1; MEL1; PFM13; PR domain 16; PR domain containing 16; PR domain zinc finger protein 16; PR domain-containing protein 16; Prdm16; Transcription factor MEL1
Goat
Ammonium sulfate precipitation
RUO
63976, 70673
-20° C, Avoid Freeze/Thaw Cycles
IgG
ChIP Assay, Flow Cytometry
0.5 mg/mL
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
A2A935, Q9HAZ2
PRDM16
Peptide with sequence C-TSESGAFHPINHL.
100 μg
Primary
Human, Mouse
Liquid
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