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Pralsetinib, MedChemExpress

Product Code. 16497327
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Product Code. 16497327

Brand: Medchem Express HY112301

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Description

MedChemExpress Pralsetinib (BLU-667) is a highly potent, selective RET inhibitor. Pralsetinib (BLU-667) inhibits WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion with IC50s of 0.4, 0.3, 0.4, 0.4, and 0.4 nM, respectively.

Pralsetinib (BLU-667) is a highly potent, selective RET inhibitor. Pralsetinib (BLU-667) inhibits WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion with IC50s of 0.4, 0.3, 0.4, 0.4, and 0.4 nM, respectively.

Specifications

Chemical Name or Material Pralsetinib
CAS 2097132-94-8
Color White
Purity Grade Notes Research
Molecular Formula C27H32FN9O2
Quantity 5 mg
Synonym BLU-667
Solubility Information DMSO : ≥ 100 mg/mL (187.41 mM)
SMILES O=C([C@@]1(OC)CC[C@H](C2=NC(NC3=NNC(C)=C3)=CC(C)=N2)CC1)N[C@H](C4=CC=C(N5N=CC(F)=C5)N=C4)C
Molecular Weight (g/mol) 533.6
Formula Weight 533.6
Percent Purity 98.39%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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