Invitrogen™ PRAK Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA582529

Product Code. 16319494

Description

Immunogen sequence: PLHSVNNPIL RKRKLLGTKP KDSVYIHDHE NGAEDSNVAL EKLRDVIAQC ILPQAGKGEN EDEKLNEVMQ EAWKYNRECK LLRDTLQSFS WNGRGFTDKV DRLKLAEIVK QVIEEQTTSH Highest antigen sequence indentity to the following orthologs: Rat - 94%, Mouse - 94%.

MAPKAPK5 (PRAK) is activated in response to cellular stress and pro-inflammatory cytokines. Activity of this kinase is regulated by p38 alpha and p38 beta. The protein encoded by PRAK is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of PRAK encoding distinct isoforms have been reported.

Specifications

• Antigen: PRAK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAPKAPK5
• Gene Alias: MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; Mapkapk5; MAPKAP-K5; MAPKAPK-5; mitogen-activated protein kinase-activated protein kinase 5; MK5; MK-5; p38-regulated/activated protein kinase; PRAK
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8550
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8IW41
• Gene Symbols: MAPKAPK5
• Immunogen: Recombinant protein corresponding to Human MAPKAPK5. Recombinant protein control fragment (Product #RP-91435).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG