Invitrogen™ PPY Monoclonal Antibody (2G5D12)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA517157

Product Code. 15398100

Description

MA5-17157 targets PPY in FACS, indirect ELISA, and WB applications and shows reactivity with Human samples. The MA5-17157 immunogen is purified recombinant fragment of human PPY (amino acids: 1-95) expressed in E. Coli. MA5-17157 detects PPY which has a predicted molecular weight of approximately 10.4kDa.

The PPY gene encodes pancreatic polypeptide, a peptide hormone involved in the regulation of appetite and energy balance. The origin of the PPY gene is linked to a tandem duplication of the PYY gene, occurring concomitantly with the emergence of tetrapods, leading to the distinct PPY function within the neuropeptide Y family. In primates and ungulates, a gene duplication event resulted in the formation of a PYY2-PPY2 gene cluster, highlighting the evolutionary complexity of these genes. The PPY gene product is secreted by gamma-cells in the pancreas, localized primarily in the islet periphery, and plays a crucial role in metabolic homeostasis by interacting with receptors in the central nervous system to modulate satiety signals postprandially. PPY's function is linked to its inhibition of AGRP/NPY neurons which decreases their suppressive effect on POMC neurons, enhancing POMC activity and contributing to appetite suppression. This intricate regulation underscores the importance of PPY in dietary intake and metabolic disorders, with ongoing research exploring its potential therapeutic applications.

Specifications

• Antigen: PPY
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: P01298
• Gene Symbols: PPY
• Immunogen: Purified recombinant fragment of human PPY (amino acids: 1-95) expressed in E. Coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Flow Cytometry, Western Blot
• Clone: 2G5D12
• Conjugate: Unconjugated
• Gene: PPY
• Gene Alias: AV061413; C-terminal peptide; HGNC:9327; IGSPP; IOPPP; Obinepitide; panceatic polypeptide; Pancreatic hormone; Pancreatic icosapeptide; Pancreatic polypeptide; pancreatic polypeptide Y; pancreatic prohormone; Pancreatic prohormone percursor; pancreatic prohormone precursor; PH; PI; PNP; PP; PP1; PPA1; PPase; Ppy; prepro-PP (prepropancreatic polypeptide); SID6-8061
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 5539
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid