Invitrogen™ PPAPDC1A Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA520864

Product Code. 12829012

Description

A suggested positive control is human brain tissue lysate. PA5-20864 can be used with blocking peptide PEP-0978.

Phosphatidate phosphatase (PAP) plays important role in lipid-signaling metabolism in eukaryotic cells. Two distinct types of PAP (PAP1 and PAP2) activity have been distinguished by their subcellular localization and differential sensitivity to N-ethylmaleimide(NEM) and Mg2+. A yeast diacylglycerol pyrophosphate (DGPP) phosphatase (DPP1) and mammalian DGPP phosphatase (PAP2) have been identified as Mg2+-independent and NEM-insensitive membrane-associated. PPAPDC1A (also known as DPPL2) and PPAPDC1B (DPPL1) form a novel type of Mg2+-independent and NEM-sensitive mammalian phosphatidate phosphatase showing broad substrate specificity. PPAPDC1A is preferentially expressed in endothelial cells. Studies of PPAPDC1A and PAP activity suggest that they may play a role in angiogenesis.

Specifications

• Antigen: PPAPDC1A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PLPP4
• Gene Alias: C030048B12Rik; diacylglycerol pyrophosphate like 2; diacylglycerol pyrophosphate phosphatase-like 2; DPPL2; Gm1090; phosphatidate phosphatase PPAPDC1A; phosphatidic acid phosphatase type 2 domain containing 1A; phosphatidic acid phosphatase type 2 domain-containing protein 1A; Phospholipid phosphatase 4; PLPP4; PPAPDC1; Ppapdc1a; RGD1306289; RP11-257O17.1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 196051, 309014, 381925
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q0VBU9, Q5VZY2
• Gene Symbols: PLPP4
• Immunogen: A 14 amino acid peptide near the carboxy terminus of human PPAPDC1A.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG