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PP 121
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Product Code. p-7116049
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Quantity:
5 mg
25 mg
Unit Size:
25mg
5mg
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Product Code. 18755856

Brand: Tocris Bioscience 3894/25

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Description

Dual kinase inhibitor; inhibits PI 3-K family kinases

PP 121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). Exhibits no significant effect on receptor serine/threonine kinases (RSTKs). Blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor.
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Specifications

Chemical Name or Material 1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 1092788-83-4
Assay Percent Range >99%
Quantity 25 mg
Molecular Formula C17H17N7
Formula Weight Observed MW: 319.36
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