PP 121

Artikelnummer. 18755856

missing translation for 'mfr': Tocris Bioscience 3894/25

Beschreibung

Dual kinase inhibitor; inhibits PI 3-K family kinases

PP 121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). Exhibits no significant effect on receptor serine/threonine kinases (RSTKs). Blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor.

Spezifikation

• Chemical Name or Material: 1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• CAS: 1092788-83-4
• Assay Percent Range: >99%
• Quantity: 25 mg
• Molecular Formula: C₁₇H₁₇N₇
• Formula Weight: Observed MW: 319.36