Invitrogen™ PON2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA595769

Product Code. 16548611

Description

Immunogen sequence: MGRLVAVGLL GIALALLGER LLALRNRLKA SREVESVDLP HCHLIKGIEA GSEDIDILPN GLAFFSVGLK FPGLHSFAPD KPGGILMMDL KEEKPRAREL RISRGFDLAS FNPHGISTFI DNDDTVYLFV VNHPEFKNTV EIFKFEEAEN SLLHLKTVKH ELLPSVNDIT AVGPAHFYAT NDHYFSDPFL KYLETYLNLH WANVVYYSPN; Positive Samples: HepG2, 293T; Cellular Location: Membrane, Peripheral membrane protein.

This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.

Specifications

• Antigen: PON2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PON2
• Gene Alias: 6330405I24Rik; A esterase 2; A-esterase 2; AI481612; aromatic esterase 2; arylesterase 2; paraoxonase 2; paraoxonase nirs; PON 2; PON2; Serum aryldialkylphosphatase 2; serum paraoxonase/arylesterase 2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5445
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.79 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q15165
• Gene Symbols: PON2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human PON2 (NP_0002962).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG