Invitrogen™ POLH Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5102492

Product Code. 16668964

Description

Antibody detects endogenous levels of total POLH.

The XPA gene encodes a zinc metalloprotein that preferentially binds to DNA damaged by UV radiation and chemical carcinogens and is required for the incision step during nucleotide excision repair The XPB and XPD genes encode DNA helicases involved in several DNA metabolic pathways, including DNA repair and transcription, and the XPG gene product is an endonuclease that cuts on the 3' side of a DNA lesion during nucleotide excision repair. Molecular defects in the XP variant (POL H) group maintain normal excision repair, yet they result in a substantial reduction in the ability to synthesize intact daughter DNA strands during DNA replication following DNA damage.

Specifications

• Antigen: POLH
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: POLH
• Gene Alias: DNA polymerase eta; DNA-directed DNA polymerase eta; FLJ16395; FLJ21978; Polh; polymerase (DNA directed), eta; polymerase (DNA directed), eta (RAD 30 related); polymerase (DNA) eta; RAD30; RAD30 homolog A; RAD30A; Xeroderma pigmentosum variant type protein; xeroderma pigmentosum variant type protein homolog; XP V; XPV; XP-V
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 316235, 5429, 80905
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q9JJN0, Q9Y253
• Gene Symbols: POLH
• Immunogen: A synthesized peptide derived from human POLH(Accession Q9Y253), corresponding to amino acid residues Q541-T591.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG