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Invitrogen™ POLG Polyclonal Antibody
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Product Code. 16620245 Shop All Thermo Scientific Products
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100 μL
Unit Size:
100µL
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16620245 100 μL 100µL
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Product Code. 16620245 Supplier Invitrogen™ Supplier No. PA5103791

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total POLG1.

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen POLG
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene POLG
Gene Accession No. P54098, P54099, Q9QYV8
Gene Alias AA409516; DNA polymerase gamma; DNA polymerase gamma subunit 1 (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha); DNA polymerase gamma, catalytic subunit; DNA polymerase subunit gamma-1; DNA-directed DNA polymerase gamma; FLJ27114; MDP1; Mip1; MIRAS; Mitochondrial DNA polymerase catalytic subunit; mitochondrial DNA polymerase gamma; mitochondrial DNA polymerase gamma catalytic subunit; mitochondrial DNA polymerase-gamma; mitochondrial polymerase gamma; MTDPS4A; MTDPS4B; PEO; Pol gamma; Polg; POLG1; POLGA; PolG-alpha; polymerase (DNA directed), gamma; polymerase (DNA) gamma, catalytic subunit; polymerase, gamma; SANDO; SCAE; truncated mitochondrial DNA polymerase gamma catalytic subunit
Gene Symbols POLG
Host Species Rabbit
Immunogen A synthesized peptide derived from human POLG(Accession P54098), corresponding to amino acid residues Y452-K502.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18975, 5428, 85472
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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