Pokemon (LRF) Armenian Hamster anti-Human, eFluor 660, Clone: 13E9, eBioscience™

Armenian Hamster Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 50-3309-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15589926

Quantity Price
1 £ 80.62 / 25µg
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Species Reactivity Human
Gene Alias Leukemia/lymphoma-related factor
Concentration 0.2mg/mL
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Conjugate eFluor 660
Format Conjugated
Monoclonal or Polyclonal Monoclonal
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Regulatory Status RUO
Primary or Secondary Primary
Isotype IgG
Quantity 25μg
Clone 1.30E+10
Host Species Armenian Hamster
Antigen Pokemon (LRF)

This monoclonal antibody reacts with human Leukemia/lymphoma-related factor (LRF). This 65kDa protein is also known as POKEMON, FBI-1, and Zbtb7a. LRF is a member of the POK family of transcriptional repressors, and is expressed in hematopoietic stem cells, T and B lymphocytes, macrophages, and erythroid cells. This protein is also highly expressed in human non-Hodgkin’s lymphoma tissues and diffuse large B-cell lymphomas, demonstrating its prominent role in oncogenic transformation. Studies have demonstrated that LRF is also involved in B cell lineage commitment and development by opposing Notch signaling. Moreover, LRF is critical for erythroid terminal differentiation in the bone marrow by inhibiting Bim-mediated apoptosis. Finally, LRF interacts with Bcl-6 in germinal center B cells.